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Corrigendum to "PEG-8000 precipitation as a rapid method for enrichment and purification of feline calicivirus" [J. Virol. Methods 344 (2026) 1-6, 115390].

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Immune Response Modulation by Caliciviruses.

Yoatzin Peñaflor-Téllez1, Adrian Trujillo-Uscanga1, Jesús Alejandro Escobar-Almazán1

  • 1Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados, IPN, Mexico City, Mexico.

Frontiers in Immunology
|October 22, 2019
PubMed
Summary

Noroviruses and Sapoviruses cause global gastroenteritis. This review explores calicivirus pathogenesis, focusing on viral protein roles in infection, replication, and immune evasion, using related viruses with available propagation systems.

Keywords:
FCVHuNoVMNVRHDVapoptosiscalicivirusimmunopathogenesisreplicative complexes

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Area of Science:

  • Virology
  • Gastroenterology
  • Immunology

Background:

  • Noroviruses and Sapoviruses are leading causes of acute gastroenteritis worldwide.
  • Limited understanding of norovirus pathogenesis due to challenges in cell culture and animal models.
  • Other Caliciviridae family members (e.g., FCV, MNV) offer accessible systems for studying viral replication and pathogenesis.

Purpose of the Study:

  • To review the pathogenic mechanisms of Caliciviridae family viruses.
  • To highlight the role of viral proteins in infection establishment and replication.
  • To discuss calicivirus-induced membrane rearrangements, apoptosis, and immune evasion strategies.

Main Methods:

  • Review of existing literature on Caliciviridae family viruses.
  • Analysis of studies utilizing cell cultures and animal models for related caliciviruses (FCV, MNV, RHDV, PS).
  • Examination of characterized viral protein functions in replication and pathogenesis.

Main Results:

  • Viral proteins play key roles in calicivirus replication cycles.
  • Mechanisms of viral protein involvement in infection establishment are increasingly understood.
  • Caliciviruses engage in membrane rearrangements, induce apoptosis, and evade host immune responses.

Conclusions:

  • Studying related caliciviruses provides insights into norovirus and sapovirus biology and pathogenesis.
  • Viral proteins are critical effectors of calicivirus infection and disease.
  • Understanding these pathogenic mechanisms is crucial for developing effective countermeasures.