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5q- syndrome terminating in acute myeloid leukemia. Karyotype evolution and immunologic characterization of blast
E Donti1, A Tabilio, G V Donti
11st Institute of Internal Medicine, School of Medicine, Perugia University, Italy.
Cancer Genetics and Cytogenetics
|June 1, 1988
Abstract:
We report a case of 5q- syndrome that progressed to acute nonlymphocytic leukemia after 9 years of clinically and morphologically stable disease. The transition from the chronic to the leukemic phase was characterized by the appearance of an additional cytogenetic anomaly [inv(2)] in the cell carrying the 5q-, together with the expansion of a clone showing an apparently normal karyotype.