Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

5.6K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.6K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.7K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.7K
Autophagic Cell Death01:18

Autophagic Cell Death

4.3K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.3K
Mitochondria01:37

Mitochondria

19.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.4K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

4.8K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
4.8K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.5K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chaperone-mediated autophagy is a tumor-suppressive mechanism in hepatocellular carcinoma.

Cell reports·2026
Same author

Chaperone-mediated autophagy is required for regulatory T cell function.

Nature communications·2026
Same author

Extracellular vesicles from Candidozyma (Candida) auris inhibit proliferation of CD4 T cells by disrupting the IL-2 axis.

Journal of immunology (Baltimore, Md. : 1950)·2025
Same author

Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus.

Annals of the rheumatic diseases·2024
Same author

Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration.

Nature communications·2022
Same journal

Epigenetic plasticity and chemoresistance in cancer: mechanisms, biomarkers, and translational opportunities for real-world evidence.

Frontiers in cell and developmental biology·2026
Same journal

Matched embryo-endometrium RNA-seq reveals coordinated but asymmetric transcriptomic reprogramming at the onset of early equine pregnancy.

Frontiers in cell and developmental biology·2026
Same journal

Myelin development in the peripheral nervous system of <i>Trachemys scripta</i>.

Frontiers in cell and developmental biology·2026
Same journal

A deep learning-based classification method for subclinical zonular laxity in AS-OCT images.

Frontiers in cell and developmental biology·2026
Same journal

Advancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies.

Frontiers in cell and developmental biology·2026
Same journal

CRISPR-based next-generation molecular diagnostics for bone infection.

Frontiers in cell and developmental biology·2026
See all related articles

Related Experiment Video

Updated: Jan 5, 2026

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells
08:35

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells

Published on: June 12, 2017

10.7K

Autophagy in T Cell Function and Aging.

Fernando Macian1

  • 1Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.

Frontiers in Cell and Developmental Biology
|October 22, 2019
PubMed
Summary
This summary is machine-generated.

Autophagy, a key cellular process, declines with age, impacting T cell function and contributing to immunosenescence. This review explores autophagy

Keywords:
T cellagingautophagychaperone-mediated autophagyimmunosenescence

More Related Videos

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

13.7K
Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
11:39

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

32.1K

Related Experiment Videos

Last Updated: Jan 5, 2026

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells
08:35

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells

Published on: June 12, 2017

10.7K
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
06:22

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells

Published on: January 9, 2019

13.7K
Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
11:39

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

32.1K

Area of Science:

  • Immunology
  • Cellular Biology
  • Aging Research

Background:

  • Autophagy dysregulation is a hallmark of aging across multiple cell types.
  • T cells exhibit reduced activity in various autophagic pathways with increasing age.

Purpose of the Study:

  • To review the role of autophagy in T cell homeostasis, differentiation, and function.
  • To explore the contribution of age-related autophagy decline to T cell immunosenescence.

Main Methods:

  • Literature review of current scientific knowledge.
  • Analysis of studies on autophagy and T cell aging.

Main Results:

  • Autophagy is crucial for maintaining T cell health and function.
  • Decreased autophagy activity in aged T cells correlates with impaired immune responses.

Conclusions:

  • Age-associated decline in autophagy significantly impacts T cell function.
  • Understanding this link is vital for addressing age-related immune dysfunction.