Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A case-control study of plasma ascorbate and acute necrotizing ulcerative gingivitis.

S L Melnick¹, J O Alvarez, J M Navia

¹Department of Epidemiology, School of Public Health, University of Alabama at Birmingham 35294.

Journal of Dental Research

|May 1, 1988

Summary

Low vitamin C (ascorbic acid) levels are linked to a higher risk of acute necrotizing ulcerative gingivitis (ANUG). This study found significantly lower plasma ascorbate in ANUG patients, suggesting a crucial role for vitamin C in preventing this gum disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Predictors of the rate of change in disease activity over time in LUMINA, a multiethnic US cohort of patients with systemic lupus erythematosus: LUMINA LXX.

Lupus·2010

Same author

Systemic lupus erythematosus in a multiethnic US cohort (LUMINA) XL II: factors predictive of new or worsening proteinuria.

Rheumatology (Oxford, England)·2006

Same author

Systemic lupus erythematosus in a multiethnic cohort: LUMINA XXXV. Predictive factors of high disease activity over time.

Annals of the rheumatic diseases·2006

Same author

Systemic lupus erythematosus in a multi-ethnic cohort (LUMINA) XXXII: [corrected] contributions of admixture and socioeconomic status to renal involvement.

Lupus·2006

Same author

Ethnic disparities in health and disease: the need to account for ancestral admixture when estimating the genetic contribution to both (LUMINA XXVI).

Lupus·2005

Same author

Systemic lupus erythematosus in a multiethnic US cohort (LUMINA): XXIV. Cytotoxic treatment is an additional risk factor for the development of symptomatic osteonecrosis in lupus patients: results of a nested matched case-control study.

Annals of the rheumatic diseases·2005

Area of Science:

Oral Health
Nutritional Science
Immunology

Background:

Ascorbate (vitamin C) plays a vital role in collagen synthesis and leukocyte function.
Previous studies suggest a link between ascorbate deficiency and acute necrotizing ulcerative gingivitis (ANUG).

Purpose of the Study:

To investigate the association between plasma ascorbate levels and ANUG.
To determine the relative risk of ANUG in individuals with low ascorbate concentrations.

Main Methods:

A case-control study involving 60 ANUG patients and 60 matched controls.
Plasma ascorbate levels were measured using a modified 2,4-dinitrophenylhydrazine method.
Dietary intake of ascorbic acid was assessed via servings per day.

Related Experiment Videos

Main Results:

ANUG cases had significantly lower mean plasma ascorbate (0.07 mmol/L) compared to controls (0.10 mmol/L).
The relative risk of ANUG was 7.3 times higher for individuals with plasma ascorbate at or below the control median.
ANUG patients consumed fewer daily servings of dietary ascorbic acid than controls.

Conclusions:

Low plasma ascorbate is significantly associated with ANUG.
Maintaining adequate vitamin C intake may be important for preventing ANUG.