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Applications for Open Source Microplate-Compatible Illumination Panels

Applications for Open Source Microplate-Compatible Illumination Panels

Published on: October 3, 2019

Applications for Open Source Microplate-Compatible Illumination Panels.

Pierre Baillargeon¹, Timothy P Spicer¹, Louis Scampavia²

¹The Scripps Research Molecular Screening Center, Department of Molecular Medicine, Scripps Florida.

Journal of Visualized Experiments : Jove

|October 22, 2019

Summary

Manual microplate preparation can be error-prone, especially with increasing well densities. The Microplate Assistive Pipetting Light Emitter (M.A.P.L.E.) system offers a semi-automated solution to improve accuracy and efficiency in laboratory settings.

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Area of Science:

Laboratory automation
Scientific instrumentation
Assay development

Background:

Microplates are essential tools in laboratory settings, from benchtop operations to high-throughput screening (HTS).
Manual microplate handling presents challenges in sample tracking, data recording, and quality control, particularly with higher well densities (96, 384, 1536).
Existing automation solutions may not always be feasible, cost-effective, or compatible with specific microplate formats.

Purpose of the Study:

To introduce a novel system, the Microplate Assistive Pipetting Light Emitter (M.A.P.L.E.), designed to aid manual microplate operations.
To enhance the accuracy and ease of sample handling in both small-scale and large-scale laboratory applications.
To provide a cost-effective solution for improving pipetting accuracy and quality control in microplate preparation.

Main Methods:

Development of a semi-automated pipetting guide system (M.A.P.L.E.).
Integration of light emission technology to guide pipetting actions.
Application of the system for tasks including compound hit-picking, assay development, and quality assurance diagnostics.

Main Results:

M.A.P.L.E. facilitates accurate sample tracking during manual microplate preparation.
The system aids in identifying well artifacts and formatting errors, improving quality control.
It supports efficient microplate preparation for various laboratory applications, including HTS and benchtop assays.

Conclusions:

The Microplate Assistive Pipetting Light Emitter (M.A.P.L.E.) system effectively addresses challenges in manual microplate handling.
M.A.P.L.E. improves accuracy, efficiency, and quality control in microplate operations.
This technology offers a valuable tool for researchers in diverse laboratory environments, enhancing experimental reproducibility.