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Circulating IGF-1 Independently Predicts Blood Pressure in Children With Higher Calcium-Phosphorus Product Levels
Sílvia Xargay-Torrent1, Estefanía Dorado-Ceballos2, Anna Benavides-Boixader1
1Pediatric Endocrinology Research Group, (Girona Biomedical Research Institute) IDIBGI, Salt, Spain.
Insights
Childhood insulin-like growth factor 1 (IGF-1) predicts systolic blood pressure (SBP), particularly in children with high calcium-phosphorus product (Ca*P) levels. This association highlights IGF-1
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Health
- Growth Factors
Background:
- Insulin-like growth factor 1 (IGF-1) plays a crucial role in childhood growth and development.
- Elevated blood pressure in childhood is a risk factor for adult cardiovascular disease.
- The interplay between growth factors and cardiometabolic markers in pediatric populations requires further investigation.
Purpose of the Study:
- To examine the association between insulin-like growth factor 1 (IGF-1) and blood pressure in children.
- To investigate the potential interaction between IGF-1 and the serum calcium-phosphorus product (Ca*P) on blood pressure.
Main Methods:
- A longitudinal study of 521 children aged 8.8 years, with 158 followed up for 5 years.
- Measurements included IGF-1, IGF-binding protein 3 (IGFBP-3), serum calcium and phosphorus, anthropometrics, and cardiometabolic variables.
- Statistical analyses involved Pearson correlations and multivariable linear regression.
Main Results:
- Baseline IGF-1 and IGF-1/IGFBP-3 molar ratio positively correlated with BMI, waist circumference, systolic blood pressure (SBP), and insulin resistance markers.
- The association between IGF-1 and SBP was stronger in children with higher Ca*P levels.
- After adjustment for confounders, IGF-1 remained an independent predictor of SBP, especially in the highest Ca*P tertile.
Conclusions:
- Childhood IGF-1 is an independent predictor of SBP in apparently healthy children.
- The predictive value of IGF-1 for SBP is particularly pronounced in children with elevated serum Ca*P levels.
- These findings suggest a potential mechanism linking growth factors and cardiovascular health in pediatric populations.
Objective:
To study the association between insulin-like growth factor 1 (IGF-1) and blood pressure in children, in particular, the potential interaction with the serum calcium-phosphorus product (Ca*P).
Methods:
A longitudinal study included 521 children (age 8.8 ± 0.1) from northeastern Spain, of whom 158 were followed-up after 5 years. IGF-1, insulin-like growth factor-binding protein 3 (IGFBP-3), and serum calcium and phosphorus were measured at baseline. Anthropometric (body-mass index [BMI] and waist) and cardiometabolic variables (systolic [SBP] and diastolic blood pressure), pulse pressure, insulin, homeostatic model assessment of insulin resistance [HOMA-IR], high-density lipoprotein [HDL]-cholesterol, and triglycerides) were assessed at baseline and at the end of follow-up. Statistical analysis included Pearson correlations followed by multivariable linear regression analyses.
Results:
Baseline IGF-1 and IGF-1/IGFBP-3 molar ratio positively correlated with baseline and follow-up BMI, waist, SBP, pulse pressure, insulin, HOMA-IR and triglycerides (r 0.138-0.603; all P < 0.05). The associations with SBP were stronger with increasing Ca*P (r 0.261-0.625 for IGF-1; and r 0.174-0.583 for IGF-1/IGFBP-3). After adjusting for confounding variables, baseline IGF-1 and IGF-1/IGFBP-3 remained independently associated with both baseline and follow-up SBP in children in the highest Ca*P tertile (β = 0.245-0.381; P < 0.01; model R2 = 0.246-0.566).
Conclusions:
Our results suggest that IGF-1 in childhood is an independent predictor of SBP in apparently healthy children, especially in those with high Ca*P levels.
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