Redox-Neutral β-C(sp3)-H Functionalization of Cyclic Amines via Intermolecular Hydride Transfer
Lan Zhou1, Yao-Bin Shen1, Xiao-De An1
1Shandong Province Key Laboratory of Applied Mycology, College of Chemistry and Pharmaceutical Sciences , Qingdao Agricultural University , Qingdao , 266109 , China.
Abstract:
Herein, we report the first redox-neutral and transition-metal-free β-C(sp3)-H functionalization of cyclic amines via a consecutive intermolecular hydride transfer process. A series of N-aryl pyrrolidines and N-aryl 1,2,3,4-tetrahydropyridines decorated with CF3 and carboxylic ester functionalities are directly accessed in good yields from pyrrolidines and piperidines. This work pushes forward the application of the intermolecular hydride transfer strategy in one-step assembly of molecular complexity.
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