Related Experiment Video
Updated: Jan 5, 2026
13:47
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
9.8K
The genetics of angle closure glaucoma
Jin Wang1, Mayinuer Yusufu2, Chiea Chuen Khor3
1Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Experimental Eye Research
|October 22, 2019
Summary
Primary angle closure glaucoma (PACG) affects millions, especially in Asia. Genetics play a key role, with environmental factors interacting with identified genetic loci to influence PACG risk.
Area of Science:
- Ophthalmology
- Genetics
- Public Health
Background:
- Primary angle closure glaucoma (PACG) is a leading cause of irreversible blindness, particularly prevalent in Asian populations.
- PACG affects over 20 million people globally, posing a significant public health challenge.
- Genetic factors are increasingly recognized as significant contributors to PACG risk.
Purpose of the Study:
- To review the current progress in understanding the genetics of PACG.
- To discuss future perspectives in PACG genetic research.
- To honor Dr. R. Rand Allingham's contributions to glaucoma genetics.
Main Methods:
- Review of recent genetic association studies in PACG.
- Analysis of identified genetic loci associated with PACG risk.
- Discussion of gene-environment interactions in PACG pathogenesis.
Main Results:
- At least eight genetic loci have been significantly associated with PACG risk.
- These genetic factors likely interact with environmental influences to contribute to PACG.
- Dr. Allingham's work significantly advanced glaucoma genetics, particularly in diverse ancestries.
Conclusions:
- Genetics are crucial in understanding PACG development.
- Further research into PACG genetics is essential for developing effective prevention and treatment strategies.
- The review serves as a tribute to Dr. Allingham's legacy in glaucoma research.
More Related Videos
10:10Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
1.8K
08:55Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
3.4K
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K
01:25Glaucoma: Overview
1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
01:27Open Angle Glaucoma: Treatment
915
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
915
01:11Genetic Lingo
113.4K
Overview
113.4K
01:28Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K
01:43Incomplete Dominance
29.5K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
29.5K