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Frequent testicular involvement in multibacillary leprosy
Hendra Gunawan1, Pati Aji Achdiat1, Rachel Marsella Rahardjo1
1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Leprosy frequently causes testicular atrophy (93.75%), often silently. Routine assessment of testicular function is recommended for leprosy patients to detect these effects.
Area of Science:
- Endocrinology
- Urology
- Infectious Diseases
Background:
- Leprosy can affect testicular function, but this is often overlooked.
- Testicular involvement in leprosy is frequently asymptomatic and underestimated.
Purpose of the Study:
- To determine the prevalence of testicular atrophy in leprosy patients.
- To evaluate the clinical, hormonal, and semen analysis consequences of testicular atrophy in leprosy.
Main Methods:
- A cross-sectional study involving 32 leprosy patients and 5 controls.
- Evaluated clinical signs, hormonal profiles (FSH, LH, testosterone), and testicular ultrasonography.
- Semen analysis was performed on a subset of patients.
Main Results:
- Testicular atrophy was found in 93.75% of leprosy patients.
- Clinical signs included loss of libido, female pubic hair pattern, gynecomastia, and infertility.
- Hormonal imbalances were noted in 16 patients, and all 10 with semen analysis showed abnormalities.
Conclusions:
- Leprosy is associated with a high rate of testicular atrophy, often without obvious symptoms.
- Routine assessment of testicular function is crucial for leprosy patients.
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