Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Autophagy01:27

Autophagy

5.6K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.6K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.7K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.7K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.1K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.1K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

8.6K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting autophagy for postsynaptic organization and cognitive rescue in Fragile X syndrome.

Neural regeneration research·2026
Same author

Extracellular Vesicles-Dependent Secretion Regulates Intracellular CYFIP2 Protein Homeostasis in Cortical Neurons.

Biomedicines·2025
Same author

Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.

Molecular psychiatry·2025
Same author

Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.

Research square·2025
Same author

Production and characterization of levans with different molecular weights synthesized by Bacillus licheniformis ZM107.

Letters in applied microbiology·2025
Same author

Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity.

Frontiers in immunology·2024

Related Experiment Video

Updated: Jan 5, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
09:10

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

7.6K

Autophagy and synaptic plasticity: epigenetic regulation.

Jee-Yeon Hwang1, Jingqi Yan2, Ruth Suzanne Zukin2

  • 1Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, USA.

Current Opinion in Neurobiology
|October 22, 2019
PubMed
Summary

Autophagy, a cellular process, is vital for neuron function and synaptic plasticity. Its dysregulation is linked to brain disorders like Alzheimer's and Parkinson's disease.

More Related Videos

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
06:58

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

1.1K
Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

2.5K

Related Experiment Videos

Last Updated: Jan 5, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
09:10

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

7.6K
Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
06:58

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

1.1K
Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

2.5K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Autophagy is essential for neuronal health, impacting axon guidance, synaptic plasticity, and overall function.
  • Dysfunctional autophagy is implicated in neurodevelopmental and neurodegenerative diseases, including autism, Parkinson's, and Alzheimer's disease.
  • Neuronal autophagy acts as a dynamic surveillance and clearance system, critical for maintaining synaptic integrity.

Purpose of the Study:

  • To review the critical role of autophagy in synaptic plasticity.
  • To explore the regulatory mechanisms of neuronal autophagy, particularly epigenetic control.

Main Methods:

  • Literature review of studies on neuronal autophagy.
  • Analysis of research on the connection between autophagy and synaptic plasticity.
  • Examination of epigenetic factors influencing autophagy in neurons.

Main Results:

  • Autophagy is indispensable for processes like dendritic spine architecture, spine pruning, and synaptic plasticity.
  • Epigenetic mechanisms play a significant role in regulating neuronal autophagy.
  • The review synthesizes current understanding of autophagy's function and regulation in neuronal health.

Conclusions:

  • Autophagy is a key player in synaptic plasticity and neuronal function.
  • Epigenetic regulation of autophagy is crucial for maintaining neuronal health.
  • Further research into autophagy and its epigenetic regulation may offer therapeutic targets for brain disorders.