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Manuela Pennisi1, Giulia Malaguarnera2,3, Giuseppe Di Bartolo4

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Low vitamin D levels are linked to increased fatigue in older adults. This study found vitamin D deficiency was common in subjects experiencing fatigue, suggesting a potential role in its management.

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Clinical Medicine

Background:

  • Fatigue is a common complaint in older adults, characterized by low energy and cognitive impairment.
  • Emerging evidence suggests a potential association between vitamin D deficiency and the experience of fatigue.

Purpose of the Study:

  • To investigate and compare vitamin D status in older individuals with and without fatigue.
  • To explore the relationship between vitamin D levels and fatigue severity in this population.

Main Methods:

  • A cohort study involving 480 older subjects (240 with fatigue, 240 controls).
  • Assessment of fatigue using the Fatigue Severity Scale and Wessely and Powell fatigue scales.
  • Measurement of 25-hydroxyvitamin D (25-OH vitamin D) and other blood parameters.

Main Results:

  • Subjects with fatigue exhibited significantly lower 25-OH vitamin D levels compared to controls.
  • While other fatigue-related blood markers were generally normal, some inflammatory markers and blood cell counts were elevated in the fatigue group.
  • Vitamin D levels showed a significant inverse correlation with fatigue severity (r = -0.428, p < 0.01).

Conclusions:

  • The study demonstrates a direct association between vitamin D status and fatigue in older adults.
  • These findings suggest that vitamin D assessment and potential supplementation could be relevant for managing fatigue in this demographic.