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Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
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Emerging Roles of DDB2 in Cancer

Pauline Gilson1, Guillaume Drouot2, Andréa Witz3

  • 1Institut de Cancérologie de Lorraine, Service de Biopathologie, Université de Lorraine, CNRS UMR 7039 CRAN, 54519 Vandœuvre-lès-Nancy CEDEX, France. p.gilson@nancy.unicancer.fr.

International Journal of Molecular Sciences
|October 23, 2019
PubMed

Insights

Damage-specific DNA-binding protein 2 (DDB2) is crucial for DNA repair and impacts cancer development. This review explores DDB2's roles in tumor progression and its clinical relevance.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Damage-specific DNA-binding protein 2 (DDB2) is a key factor in DNA repair pathways, particularly global genomic nucleotide excision repair (GG-NER).
  • Beyond DNA repair, DDB2 influences critical cellular processes including chromatin remodeling, gene transcription, cell cycle control, and protein degradation.
  • Emerging evidence highlights DDB2's significant involvement in the development and progression of various cancers.

Purpose of the Study:

  • To review the current scientific understanding of DDB2's biological effects on tumor development.
  • To elucidate the molecular mechanisms by which DDB2 influences carcinogenesis.
  • To provide insights into the clinical implications of DDB2 activity in cancer.

Main Methods:

  • Literature review of existing studies on DDB2.
  • Analysis of molecular mechanisms underlying DDB2's role in cancer.
  • Synthesis of clinical data related to DDB2 in various cancers.

Main Results:

  • DDB2 activity is implicated in multiple stages of carcinogenesis, including cancer cell proliferation, survival, and metastasis.
  • DDB2 influences epithelial to mesenchymal transition, migration, invasion, angiogenesis, and cancer stem cell formation.
  • The molecular pathways connecting DDB2 function to tumor progression are complex and multifaceted.

Conclusions:

  • DDB2 plays a multifaceted role in cancer development, acting as a significant contributor to tumor progression.
  • Understanding DDB2's molecular functions is crucial for developing targeted cancer therapies.
  • Further research into DDB2's clinical consequences may lead to novel diagnostic and therapeutic strategies in oncology.
Keywords:
DDB2DNA repaircancersinvasionmigrationproliferation

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