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Platelets in Inflammation and Resolution

Andreas Margraf1, Alexander Zarbock2

  • 1Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, 48149 Muenster, Germany.

Journal of Immunology (Baltimore, Md. : 1950)
|October 23, 2019
PubMed

Platelets have long been known for their role in hemostasis. In this, platelet adhesion and activation leads to the formation of a firm thrombus and thus the sealing of a damaged blood vessel. More recently, inflammatory modes of function have been attributed to these non-nuclei-containing cellular fragments. Interaction with leukocytes, secretion of proinflammatory mediators, and migratory behavior are some of the recent discoveries. Nonetheless, platelets also have anti-inflammatory potential by regulating macrophage functions, regulatory T cells, and secretion of proresolving mediators. This review summarizes current knowledge of platelet functions with a special focus on inflammation and resolution of inflammation.

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