Related Experiment Video
Updated: Jan 5, 2026
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
14.1K
Oncometabolites in renal cancer
Cissy Yong1,2, Grant D Stewart3,4, Christian Frezza5
1Department of Surgery, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Nature Reviews. Nephrology
|October 23, 2019
Summary
Oncometabolites, or cancer-promoting metabolites, are key to understanding tumor growth. Aberrant accumulation of these molecules, like fumarate and succinate, offers new diagnostic and therapeutic strategies in oncology.
Area of Science:
- Oncology
- Cancer Metabolism
- Biochemistry
Background:
- Cancer metabolism research has expanded beyond proliferation to include the role of oncometabolites in tumorigenesis.
- Oncometabolites are conventional metabolites with pro-oncogenic functions when abnormally accumulated.
- Their discovery revives interest in the Warburg hypothesis regarding aberrant metabolism as a cause of cancer.
Purpose of the Study:
- To explore the role of oncometabolites in cancer.
- To identify oncometabolites as potential diagnostic and prognostic biomarkers.
- To investigate oncometabolites as novel therapeutic targets in oncology.
Main Methods:
- Characterization of fumarate, succinate, L-2-hydroxyglutarate (L-2-HG), and D-2-hydroxyglutarate (D-2-HG) as oncometabolites.
- Investigating metabolic reprogramming in renal cell carcinoma (RCC).
- Analyzing the inhibitory effects of oncometabolites on α-ketoglutarate-dependent dioxygenases.
Main Results:
- Fumarate, succinate, and L-2-HG are implicated in renal cell carcinoma (RCC) progression.
- These oncometabolites inhibit α-ketoglutarate-dependent dioxygenases, causing epigenetic dysregulation and pseudohypoxic phenotypes.
- Oncometabolites possess specific pro-oncogenic capabilities.
Conclusions:
- Oncometabolites play a significant role in cancer development and progression.
- Oncometabolites, particularly fumarate, succinate, and L-2-HG, are implicated in RCC.
- Oncometabolites present opportunities for developing targeted therapies and biomarkers for cancer treatment.
More Related Videos
Related Concept Videos
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
03:03mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K
02:30Metastasis
6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K
01:20The Retinoblastoma Gene
4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
02:50Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
02:18Cancer
53.3K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.3K