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Updated: Jan 5, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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MRI-derived markers for predicting a decline in renal function in patients with autosomal dominant polycystic kidney

Ewa Banach-Ambroziak1, Magdalena Jankowska2, Małgorzata Grzywińska3

  • 1University Medical Centre of Gdansk, Poland.

Polish Journal of Radiology
|October 23, 2019
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) progression varies. Height-adjusted total kidney volume, measured via MRI, is a key biomarker for identifying patients who will benefit most from new therapies.

Area of Science:

  • Nephrology
  • Medical Imaging
  • Genetics

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease in Europe.
  • Disease progression in ADPKD exhibits significant inter-patient variability.
  • Identifying rapidly progressing ADPKD cases is crucial for targeted pharmacotherapy and clinical trial enrollment.

Purpose of the Study:

  • To highlight the importance of identifying ADPKD patients with the fastest disease progression.
  • To advocate for the adoption of specific biomarkers for monitoring ADPKD.
  • To emphasize the role of advanced imaging in assessing ADPKD severity.

Main Methods:

  • The study focuses on the continuous, exponential increase in kidney volume in early-stage ADPKD.
  • It proposes height-adjusted total kidney volume as a mandatory diagnostic biomarker.
  • It suggests quantitative MRI techniques as promising tools for evaluating disease severity.

Main Results:

  • Traditional markers of ADPKD severity remain unchanged in early stages.
  • Kidney volume increases exponentially, making it a reliable indicator of progression.
  • Quantitative MRI offers potential for deeper insights into ADPKD's course.

Conclusions:

  • Height-adjusted total kidney volume should be a standard diagnostic measure for ADPKD.
  • Quantitative MRI techniques show promise as biomarkers for ADPKD severity and progression.
  • Accurate patient stratification is essential for optimizing treatment and research in ADPKD.
Keywords:
MRIautosomal dominant polycystic kidney diseasetotal kidney volume

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