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Protective Effects of Specneuzhenide on Renal Injury in Rats with Diabetic Nephropathy
Jiangning Yin1, Jun Jiang2, Huajun Wang3
1Department of Emergency, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China.
Background:
We aim to investigate the protective effects and potential mechanisms in specneuzhenide (SPE) on renal injury in rats with diabetic nephropathy (DN).
Results:
SPE could inhibit the decrease of body weight compared with the model group (P<0.05), and trigger improvement in the renal index (P<0.05). High dose and low dose SPE could trigger a significant decrease in serum IL1β, IL-6 and TNF-α compared with the model group (P<0.05). SPE could attenuate the glomerular lesions in DN rats. SPE induced up-regulation of podocin and CD2AP (P<0.05).
Conclusion:
SPE showed protective effects on renal injury through attenuating the pathological injury and urine protein. This process may be closely related to the modulation of CD2AP and podocin expression.
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