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Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...

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Related Experiment Video

Updated: Jan 5, 2026

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients

Published on: September 1, 2023

Synchronization lag in post stroke: relation to motor function and structural connectivity.

Xin Wang¹, Caio Seguin², Andrew Zalesky²

¹Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.

Network Neuroscience (Cambridge, Mass.)

|October 23, 2019

Summary

This summary is machine-generated.

Stroke disrupts brain communication, causing delays. This study links stroke-related brain damage to reduced network efficiency, explaining information transfer lags and motor deficits.

Keywords:

Brain navigation Chronic stroke Functional lag Motor function Network efficiency

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Area of Science:

Neuroscience
Medical Imaging
Systems Biology

Background:

Stroke often causes delays in resting-state hemodynamic responses, leading to neural synchronization lags between brain regions.
The underlying structural reasons for these lags after stroke are not well understood.

Purpose of the Study:

To investigate the structural basis of synchronization lag in individuals with stroke using resting-state functional MRI (rs-fMRI).
To determine if brain network communication efficiency explains variations in synchronization lag profiles.

Main Methods:

Used rs-fMRI to assess synchronization lag between homotopic regions in stroke patients and healthy controls.
Mapped structural brain networks (connectomes) using diffusion MRI.
Evaluated network communication efficiency using shortest path and navigation schemes.

Main Results:

Interindividual differences in synchronization lags inversely correlated with brain network communication efficiency.
Interregional lag variations were associated with navigation efficiency and distance, influenced by structural constraints.
Greater motor deficit severity in stroke patients correlated with increased average synchronization lag.

Conclusions:

Established a structural foundation for delayed interregional information transfer observed in stroke patients via rs-fMRI.
Highlighted the clinical relevance of structural-functional connectivity in stroke by linking lags to motor deficits.