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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Palliative care interventions for people with multiple sclerosis.

Carolina Oc Latorraca1, Ana Luiza C Martimbianco, Daniela V Pachito

  • 1Cochrane Brazil, Centro de Estudos de Saúde Baseada em Evidências e Avaliação Tecnológica em Saúde, Rua Borges Lagoa, 564 cj 63, São Paulo, SP, Brazil, 04038-000.

The Cochrane Database of Systematic Reviews
|October 23, 2019
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Summary

Palliative care interventions show uncertain benefits for multiple sclerosis (MS) patients. More research is needed to determine their effectiveness in improving quality of life and managing symptoms for individuals with MS.

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Area of Science:

  • Neurology
  • Palliative Care
  • Clinical Trials

Background:

  • Multiple sclerosis (MS) presents complex physical and daily living challenges.
  • Palliative care teams offer expertise in symptom management, communication, and decision-making support.
  • Despite advances, MS remains a life-limiting disease impacting patients and families.

Purpose of the Study:

  • To evaluate the benefits and harms of palliative care interventions versus usual care for all forms of multiple sclerosis.
  • To compare the effects of different palliative care interventions.

Main Methods:

  • Conducted a comprehensive literature search up to October 2018, including multiple databases and registries.
  • Included randomized controlled trials (RCTs) and cluster randomized trials comparing palliative care with usual care or other palliative interventions.
  • Assessed risk of bias and summarized key outcomes at six or more months post-intervention.

Main Results:

  • Three studies with 146 participants met the criteria, focusing on home-based palliative care.
  • No significant differences were found in long-term quality of life, serious adverse events, or hospital admissions.
  • Key outcomes like fatigue, anxiety, depression, and disability were not assessed long-term.

Conclusions:

  • Current evidence is insufficient to confirm the benefits of palliative care for multiple sclerosis.
  • Low to very low certainty evidence exists for long-term quality of life, adverse events, and hospital admissions.
  • Uncertainty remains regarding palliative care's effects on quality of life, disability, anxiety, and depression in the intermediate term.