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Cell mechanical microenvironment for cell volume regulation.

Meng Wang1,2, Yaowei Yang1,2, Lichun Han1,2,3

  • 1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Journal of Cellular Physiology
|October 23, 2019
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Summary

Cell volume regulation is crucial for cell homeostasis and function. This review explores how cells maintain volume against mechanical forces and its role in mechanotransduction.

Keywords:
cell cortical tensioncell mechanical microenvironmentcell volume regulationmechanotransduction

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Area of Science:

  • Cell Biology
  • Biophysics
  • Mechanobiology

Background:

  • Cell volume regulation is a fundamental homeostatic process.
  • Environmental mechanical cues significantly influence cell volume regulation.
  • The interplay between cell volume and mechanotransduction is increasingly recognized.

Purpose of the Study:

  • To review mechanisms of cell volume homeostasis in vivo and in vitro.
  • To elucidate the role of cell cortex/membrane tension in mediating mechanical cues' effects on cell volume.
  • To highlight cell volume as an integrator of mechanotransduction signals and an indicator of mechanical conditions.

Main Methods:

  • Literature review of existing studies on cell volume regulation and mechanotransduction.
  • Discussion of growth-division regulation in maintaining cell volume homeostasis during the cell cycle.
  • Analysis of how cell cortex/membrane tension mediates responses to osmotic pressure, matrix stiffness, and mechanical force.

Main Results:

  • Cell volume regulation is influenced by growth-division dynamics and cell cycle progression.
  • Cell cortex and membrane tension are key mediators of mechanical cues' impact on cell volume.
  • Cell volume acts as a critical integrator and indicator of mechanotransduction pathways.

Conclusions:

  • Cell volume regulation is intrinsically linked to mechanotransduction.
  • Understanding cell volume's role offers insights into biomechanics, bioengineering, and pathology.
  • Further research into cell volume in mechanotransduction is warranted.