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Updated: Jan 5, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Bacterial resistance to antimicrobial peptides
Milad Abdi1,2, Shiva Mirkalantari2, Nour Amirmozafari2
1Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
Antimicrobial peptides (AMPs) or host defense peptides (HDPs) are vital components of human innate defense system targeting human-related bacteria. Many bacteria have various mechanisms interfering with AMP activity, causing resistance to AMPs. Since AMPs are considered as potential novel antimicrobial drugs, understanding the mechanisms of bacterial resistance to direct killing of AMPs is of great significance. In this review, a comparative overview of bacterial strategies for resistance to direct killing of various AMPs is presented. Such strategies include bacterial cell envelope modification, AMP degradation, sequestration, expelling, and capsule.
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