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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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A modern approach to the treatment of plaque psoriasis

Daniela Ledić Drvar1, Tomislav Vlahinić2, Željan Maleš3

  • 1Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, HR-10000Zagreb, Croatia.

Acta Pharmaceutica (Zagreb, Croatia)
|October 23, 2019
PubMed

Insights

Psoriasis is a chronic inflammatory skin condition affecting 1.6% of the Croatian population. Its development involves genetics, immune issues, and environmental factors, with targeted therapies advancing personalized medicine.

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Psoriasis is a prevalent chronic inflammatory skin disease affecting 0.5-3% globally and 1.6% in Croatia.
  • Disease prevalence shows a bimodal distribution with peaks in young adulthood (20-30) and later adulthood (50-60).
  • Multifactorial etiopathogenesis involves genetic predisposition, immune dysregulation, environmental triggers, and compromised skin barrier function.

Purpose of the Study:

  • To review the epidemiology, etiopathogenesis, clinical variants, and treatment strategies for psoriasis.
  • To highlight the role of key signaling pathways such as TNF-α, IL-23, and IL-17.
  • To discuss the evolution towards personalized medicine in psoriasis management.

Main Methods:

  • Literature review of epidemiological data, etiological factors, and therapeutic approaches.
  • Analysis of key molecular pathways implicated in psoriasis pathogenesis.
  • Examination of current and emerging treatment modalities.

Main Results:

  • Psoriasis affects diverse age groups with distinct epidemiological patterns.
  • Genetic and immunological factors, alongside environmental influences, are central to disease development.
  • Targeted therapies are crucial for moderate-to-severe cases unresponsive to conventional treatments.

Conclusions:

  • Understanding psoriasis's complex etiology is key to effective management.
  • Advancements in immunogenetics are driving the development of personalized treatment strategies.
  • The future of psoriasis care lies in tailored, targeted therapeutic interventions.

Keywords:
biologicalsconventional systemic therapypsoriasissmall moleculestopical treatment

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