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Related Concept Videos

The Parathyroid Glands00:59

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Analytical Differences in Intraoperative Parathyroid Hormone Assays.

Edward K Y Leung1, Christine C Lee2, Peter Angelos3

  • 1Department of Pathology, Pritzker School of Medicine, The University of Chicago, Chicago, IL; edleung@chla.usc.edu.

The Journal of Applied Laboratory Medicine
|October 23, 2019
PubMed
Summary
This summary is machine-generated.

This study compared two intraoperative parathyroid hormone (PTH) assays, finding the Roche assay showed slower PTH decline in 20% of patients. Operating room testing offered a slightly faster turnaround time (TAT) than the central laboratory.

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Area of Science:

  • Clinical Chemistry
  • Endocrinology
  • Surgical Pathology

Background:

  • Intraoperative parathyroid hormone (PTH) monitoring is crucial for parathyroidectomy success.
  • Assessing the performance of different PTH assays in real-time surgical settings is essential.
  • Short turnaround time (TAT) PTH assays are increasingly used in operating rooms.

Purpose of the Study:

  • To compare the analytical performance and TAT of Siemens Immulite® Turbo PTH and Roche Elecsys® PTH assays.
  • To investigate differences in PTH decline rates between the two assays during surgery.
  • To evaluate the impact of testing location (operating room vs. central laboratory) on TAT.

Main Methods:

  • 95 patients undergoing parathyroidectomy were included in the study.
  • Serial blood samples were analyzed using both Siemens Immulite® and Roche Elecsys® PTH assays.
  • Turnaround time (TAT) was compared for assays performed in the operating room (OR) versus the central clinical chemistry laboratory (CCL) for the first 15 patients.

Main Results:

  • A statistically significant difference in TAT was observed, with OR testing being faster (median 20 min) than CCL testing (median 27 min; P < 0.05).
  • Slower rates of parathyroid hormone (PTH) decline were noted in approximately 20% of patients when using the Roche assay compared to the Immulite assay.
  • The median TAT difference between OR and CCL was approximately 7 minutes.

Conclusions:

  • Operating room testing of PTH assays yields a slightly shorter TAT compared to central laboratory analysis.
  • While both assays demonstrated comparable PTH decline rates for most patients, the Roche assay exhibited slower PTH decline in about 20% of cases.
  • These findings highlight potential inter-assay variability in intraoperative PTH monitoring and the impact of testing location on TAT.