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Component-Resolved Diagnosis in Allergic Rhinitis and Asthma
Kathrin Eiringhaus1, Harald Renz1, Paolo Matricardi2
1Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany.
The Journal of Applied Laboratory Medicine
|October 23, 2019
Summary
Molecular allergy diagnostics, including component-resolved diagnosis (CRD), improve allergic rhinitis and asthma management. CRD aids in identifying allergen causes and optimizing immunotherapy, reducing unnecessary testing.
Area of Science:
- Allergy and Immunology
- Respiratory Medicine
Background:
- Allergic rhinitis and asthma are prevalent chronic inflammatory diseases impacting quality of life and healthcare costs.
- Both conditions are linked to specific IgE (sIgE) against aeroallergens.
Purpose of the Study:
- To review the significance of molecular allergy diagnostics in managing allergic rhinitis and asthma.
- To highlight the role of component-resolved diagnosis (CRD) in complex allergy cases.
Main Methods:
- The review examines the
- U-shaped
- approach, integrating conventional diagnostics with CRD.
- Focuses on CRD's utility in identifying sensitization patterns and cross-reactivity.
Main Results:
- CRD provides crucial information for complex cases like polysensitization, aiding in allergen identification.
- Molecular sensitization patterns influence immunotherapy choices and reduce overprescription.
- CRD helps uncover cross-reactivity, particularly with inhalant allergens like Fel d 1 and Can f 1.
Conclusions:
- Molecular allergy diagnostics, including CRD, offer valuable insights beyond traditional methods.
- CRD enhances the assessment of sensitization profiles and treatment responsiveness.
- The integration of CRD into clinical routine improves patient management for allergic diseases.
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