Related Experiment Video
Updated: Jan 5, 2026

Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique
Published on: June 12, 2015
Single and Multi-Objective Optimization of a Three-Dimensional Unbalanced Split-and-Recombine Micromixer
Wasim Raza1, Sang-Bum Ma2, Kwang-Yong Kim3
1Department of Mechanical Engineering, Inha University, Incheon 22212, Korea. wasimkr@live.in.
Abstract:
The three-dimensional geometry of a micromixer with an asymmetrical split-and-recombine mechanism was optimized to enhance the fluid-mixing capability at a Reynolds number of 20. Single and multi-objective optimizations were carried out by using particle swarm optimization and a genetic algorithm on a modeled surrogate surface. Surrogate modeling was performed using the computational results for the mixing. Mixing and flow analyses were carried out by solving the convection-diffusion equation in combination with the three-dimensional continuity and momentum equations. The optimization was carried out with two design variables related to dimensionless geometric parameters. The mixing effectiveness was chosen as the objective function for the single-objective optimization, and the pressure drop and mixing index at the outlet were chosen for the multi-objective optimization. The sampling points in the design space were determined using a design of experiment technique called Latin hypercube sampling. The surrogates for the objective functions were developed using a Kriging model. The single-objective optimization resulted in 58.9% enhancement of the mixing effectiveness compared to the reference design. The multi-objective optimization provided Pareto-optimal solutions that showed a maximum increase of 48.5% in the mixing index and a maximum decrease of 55.0% in the pressure drop in comparison to the reference design.
Related Concept Videos
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Multi-input and Multi-variable systems
In the absence of...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Racemic Mixtures and the Resolution of Enantiomers
Three-Compartment Open Model
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...

