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Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma

Po-Shuan Huang1,2, Chia-Siu Wang3, Chau-Ting Yeh4

  • 1Department of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 33302, Taiwan. leo_6813@msn.com.

International Journal of Molecular Sciences
|October 24, 2019
PubMed

Insights

This review explores how thyroid hormone influences microRNAs (miRNAs) linked to oxidative stress in liver cancer. Understanding these connections may reveal new therapeutic targets for this disease.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Oxidative stress, an imbalance of reactive oxygen species (ROS), damages cellular components and contributes to diseases like cancer.
  • MicroRNAs (miRNAs) are increasingly recognized for their roles in cellular processes and cancer development.
  • The interplay between oxidative stress, miRNAs, and liver cancer, particularly involving thyroid hormone, requires further elucidation.

Purpose of the Study:

  • To review the effects of thyroid hormone on oxidative stress-related miRNAs in liver cancer.
  • To investigate the potential positive or negative impact of these interactions on liver cancer progression.
  • To synthesize current evidence on the relationships among thyroid hormone, miRNAs, and oxidative stress in the context of liver cancer.

Main Methods:

  • Literature review synthesizing findings from clinical and animal studies.
  • Analysis of existing research on miRNA regulation by oxidative stress.
  • Examination of the role of thyroid hormone in liver cancer pathophysiology.

Main Results:

  • Oxidative stress-induced miRNAs are implicated in liver cancer development and progression.
  • Thyroid hormone may modulate the activity of specific miRNAs involved in oxidative stress pathways.
  • Evidence suggests a complex relationship between thyroid hormone, miRNAs, and oxidative stress in liver cancer, with potential implications for disease outcome.

Conclusions:

  • Thyroid hormone's influence on oxidative stress-related miRNAs presents a potential avenue for understanding and treating liver cancer.
  • Further research is needed to fully delineate the specific mechanisms and therapeutic potential of targeting these interactions.
  • This review highlights the need for integrated approaches considering thyroid hormone, miRNAs, and oxidative stress in liver cancer research.
Keywords:
liver cancermicroRNAoxidative stressthyroid hormone

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