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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Delivery Pathways to the Lysosome01:36

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
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Nephrons01:10

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Autophagic Cell Death01:18

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Related Experiment Video

Updated: Jan 5, 2026

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells
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Autophagy in Kidney Disease.

Mary E Choi1,2

  • 1Joan and Sanford I. Weill Department of Medicine, Division of Nephrology and Hypertension, Weill Cornell Medicine, New York, NY 10065, USA;

Annual Review of Physiology
|October 24, 2019
PubMed
Summary

Autophagy, a cellular process for waste removal, plays a key role in kidney diseases. Modulating autophagy may offer new treatments for various kidney disorders.

Keywords:
acute kidney injuryautophagychronic kidney diseaseinflammationmitophagy

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Pathology

Background:

  • Autophagy is a fundamental cellular process responsible for maintaining homeostasis through the degradation of cellular components.
  • Dysregulation of autophagy is increasingly linked to the pathogenesis of various human diseases.
  • Selective autophagy pathways, such as mitophagy and aggrephagy, are critical for cellular quality control.

Purpose of the Study:

  • To review the multifaceted roles of autophagy in the context of kidney diseases.
  • To highlight the involvement of autophagy in acute and chronic kidney injury.
  • To explore the therapeutic potential of targeting autophagy in renal disorders.

Main Methods:

  • Literature review of studies investigating autophagy in kidney disease models and human patients.
  • Analysis of evidence linking macroautophagy and selective autophagy to renal pathologies.
  • Synthesis of current understanding of autophagy's role in conditions like acute kidney injury, diabetic nephropathy, and polycystic kidney disease.

Main Results:

  • Autophagy is implicated in acute kidney injury resulting from toxins, sepsis, and ischemia/reperfusion.
  • Autophagy plays significant roles in chronic kidney diseases, including diabetic kidney disease and COPD-associated kidney injury.
  • Evidence suggests involvement of autophagy in polycystic kidney disease and kidney cancer.

Conclusions:

  • Autophagy is a critical regulator in the development and progression of diverse kidney diseases.
  • Targeting the autophagy pathway presents a promising therapeutic strategy for managing kidney disorders.
  • Further research into autophagy modulation could lead to novel treatments for renal pathologies.