Is short-course systemic antibiotic therapy using an antibiotic-loaded cement spacer safe after resection for...

Most patients who undergo two-stage exchange arthroplasty surgery for total knee arthroplasty prosthetic joint infection (TKA-PJI) receive a six-week course of systemic antibiotic treatment after the first stage procedure. However, the optimal duration of therapy has not been conclusively determined.

We included 64 patients with periprosthetic knee infection who had undergone two-stage exchange arthroplasty. Between March 2003 and December 2009, 21 patients were given a short-course (less than 1 week) antibiotic treatment, and 43 were given a standard-course (4-6 weeks) treatment during the interim period. We compared length of hospital stay, duration of intravenous and overall systemic antibiotic treatments, and rate of recurrent periprosthetic knee infection between groups.

Short-course antibiotic treatment was associated with a shorter hospital stay and a shorter duration of intravenous and systemic antibiotic treatment. Implant survival regarding re-resection arthroplasty and chronic oral antibiotic suppression as primary endpoints was not significant different statistically between two groups (p = 0.317). The 1-year implant survival rates were 91.7% in the short-course group and 89.8% in the standard-course group. The 5-year implant survival rates were 85.2% and 74.0%, respectively.

After the first stage of resection arthroplasty for a two-stage exchange arthroplasty, a short course of antibiotic treatment had similar implant survival rates in comparison to the standard 6-week course. With radical debridement combined with an antibiotic-loaded cement spacer along with serial monitoring of the patient, a short course antibiotic treatment may be adequate in patients with TKA-PJI.