Optimization of Inositol Hexaphosphate Colon Targeted Formulation for Anticarcinogenic Marker Modulation

Area of Science:

• Oncology
• Pharmacology
• Biomaterials Science

Background:

• Colorectal cancer is a leading cause of cancer death globally.
• Natural compounds like inositol hexaphosphate (IP6) show promise as anticancer agents.
• IP6's rapid excretion limits its therapeutic potential for colon cancer.

Purpose of the Study:

• To develop a colon-targeted drug delivery system for inositol hexaphosphate (IP6).
• To overcome IP6's rapid excretion and enhance its efficacy against colon cancer.
• To formulate and characterize IP6-loaded biodegradable microspheres.

Main Methods:

• IP6-loaded microspheres were prepared using a biodegradable polymer via solvent evaporation.
• Formulations were evaluated for yield, encapsulation efficiency, particle size, and drug release.
• In vivo studies utilized DMH-induced colon tumors in Albino Wistar rats.

Main Results:

• Optimized microspheres exhibited a particle size of 92 ± 0.76 μm.
• Entrapment efficiency was 67.26% ± 0.75%, with 15.74% drug loading.
• In vitro release reached 82.36% ± 0.51%; in vivo studies showed biomarker modulation and architectural restoration.

Conclusions:

• IP6-loaded pectin microspheres are a viable colon-targeted delivery system.
• The formulation effectively delivered IP6 to the colon, demonstrating significant anticancer activity.
• This approach offers a promising strategy for preventing and treating colon carcinomas.