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05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
856
Updates on Monogenic Obesity in a Multifactorial Disease
Jared Baxter1, Priscila Rodrigues Armijo2, Laura Flores1
1College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Obesity Surgery
|October 24, 2019
Summary
Genetic factors significantly influence obesity development. This review examines four key genes—leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor—and their roles in obesity predisposition, progression, and treatment.
Area of Science:
- Genetics and Molecular Biology
- Endocrinology
- Public Health
Background:
- Obesity is a global epidemic with increasing prevalence.
- The complex pathogenesis of obesity is not fully understood.
- Genetic factors play a crucial role in obesity development and personalized medicine.
Purpose of the Study:
- To review the genetic drivers of obesity.
- To focus on four specific genes linked to obesity through genome-wide association studies.
- To explore the involvement of these genes in obesity predisposition, progression, and prognosis.
Main Methods:
- Narrative review of current literature.
- Focus on genome-wide association study-documented genes.
- Detailed examination of four specific genes: leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor.
Main Results:
- Leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor are identified as key genes associated with obesity.
- These genes are implicated in the predisposition, progression, and prognosis of obesity.
- Current literature on the pathogenesis and available treatments for mutations in these genes is elaborated.
Conclusions:
- Genetic mutations in leptin, leptin receptor, POMC, and MC4R contribute to obesity.
- Understanding these genetic links is vital for personalized obesity treatment strategies.
- Further research into gene-environment interactions is needed for comprehensive obesity management.
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