Related Experiment Video
Updated: Jan 5, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
Published on: December 22, 2020
Crosstalk between cancer-associated fibroblasts and immune cells in cancer
Yuanyuan An1, Fengtian Liu1, Ying Chen1
1Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, P.R. China.
Abstract:
Multiple studies have shown that cancer-associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression.
More Related Videos
Related Concept Videos
The Tumor Microenvironment
Introduction to Fibroblasts
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Cell Migration through Invadopodia
Regulation of Hematopoietic Stem Cells

