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A new phenolic acid from the wood of Mangifera gedebe
Hai Xuan Nguyen1, Loc Thanh Nguyen1, Truong Nhat Van Do1
1Faculty of Chemistry, VNUHCM-University of Science, Hochiminh City, Vietnam.
Abstract:
From the methanol extract of the wood of Mangifera gedebe (Anacardiaceae), we had isolated a new secondary metabolite named gedebic acid (1) and six known compounds (2-7). Their chemical structures were determined by spectroscopic methods as well as comparing with data in the literature. All compounds were tested for α-glucosidase inhibitory activity. Compounds 4-7 showed more potent inhibitory activity, with IC50 values ranging from 45.3 to 142.6 μM, than that of a positive control acarbose (IC50, 214.5 μM).
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