Five polyketides isolated from the marine-derived fungus Arthrinium Sp
Zhaihai Zhao1, Wanjing Ding1, Pin-Mei Wang1
1Institute of Marine Biology & Pharmacology, Ocean College, Zhejiang University, Zhoushan, China.
Abstract:
Four new polyketides including two arthrinic acid derivatives (1-2), one phenolic derivative (3) and (S)-3-hydroxy-6-(2-hydroxypropyl)-5-methyl-2H-pyran-2-one (4) along with one methyl ester of arthrinic acid (5) were isolated from the culture broth of Arthrinium sp., which was an entophytic fungus of clam worm. Their structures were identified on the basis of HR-ESI-MS and NMR spectral analyses together with advanced Mosher's method. In the assay of inhibiting the prostate cancer PC3 cell line, none of the isolated compounds showed significant cytotoxicity.
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