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Related Concept Videos

Drug Classes and Categories01:25

Drug Classes and Categories

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Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
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Drug Products: Biologics, Biosimilars and Interchangeables01:28

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Body:Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Prescription, Nonprescription and Orphan Drugs01:02

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Related Experiment Video

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Pharmaceutical implants: classification, limitations and therapeutic applications.

Zahra Mohtashami1, Zahra Esmaili1, Molood Alsadat Vakilinezhad1

  • 1Pharmaceutics Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Pharmaceutical Development and Technology
|October 24, 2019
PubMed
Summary

Implantable drug delivery systems offer advantages over traditional methods, overcoming limitations in various medical fields. This review evaluates their benefits in chemotherapy, contraception, pain management, and more.

Keywords:
Pharmaceutical implantschemotherapeutical implantscontraceptive implantsocular deliverypain managementpeptide delivery

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Controlled/sustained drug delivery systems are rapidly advancing, addressing limitations of traditional methods.
  • Biomedical and biomaterial science developments have increased focus on implantable delivery systems.
  • Advances in polymer science enable diverse implantable system production.

Purpose of the Study:

  • To review the development and pharmaceutical applications of implantable drug delivery systems.
  • To evaluate the advantages of these systems across various medical disciplines.
  • To provide a historical perspective on the evolution of implantable delivery technologies.

Main Methods:

  • Literature review of controlled/sustained release systems.
  • Analysis of pharmaceutical applications in diverse medical fields.
  • Evaluation of implantable systems in chemotherapy, contraception, and pain management.

Main Results:

  • Implantable systems demonstrate significant benefits in multiple therapeutic areas.
  • These systems offer improved drug efficacy and patient compliance.
  • Ongoing research focuses on refining properties and overcoming existing challenges.

Conclusions:

  • Implantable drug delivery systems are integral to modern medicine.
  • Their versatility spans numerous applications, from oncology to orthopedics.
  • Continued innovation promises further enhancements in therapeutic outcomes.