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Updated: Jan 5, 2026
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated
Tomoki Nishimura1, Naoki Sumi1, Sada-Atsu Mukai1
1Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. nishimura.tomoki.6w@kyoto-u.ac.jp akiyoshi@bio.polym.kyoto-u.ac.jp.
Abstract:
An approach for the preparation of self-healing and injectable hydrogels based on the crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s is reported. Hydrogelation does not require any organic solvents, as the polymers dissolve in water below their lower critical solution temperatures. The transplanted hydrogels cause no significant foreign-body response. Considering the simplicity of the method and the biocompatibility of the resulting injectable hydrogels, crystallization-driven hydrogelation of poly(oxazoline)-based polymers may potentially be used in a wide range of biomedical applications.
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