[Experimental study of truncal vagotomy for healing of highly located gastric ulcer]

In order to investigate whether truncal vagotomy effects on the wound-healing of highly located gastric ulcer or not, the ratio of epithelialization of ulcer, gastric acidity, mucosal blood flow, mucosal PGE2 and labelling index of mucosa after vagotomy were studied by using the mongrel dogs which were prepared highly located penetrated gastric ulcer. Following results were obtained. 1. The ratio of epithelialization of vagotomized dogs at the third week after preparing ulcer showed significant high ratio compared with non-vagotomized dogs. Comparing thoracic truncal vagotomy with abdominal truncal vagotomy, the former was more effective than the latter. 2. Mucosal blood flow and gastric acidity were reduced after vagotomy. 3. Mucosal PGE2 decreased at the first week after vagotomy, however, reduced PGE2 recovered up-to the level with non-vagotomized dogs at the second week after thoracic truncal vagotomy and at the third week after abdominal truncal vagotomy, respectively. 4. Labelling indexes showed significant high counts after vagotomy compared with non-vagotomy. In conclusion, it was suggested that truncal vagotomy would be effective on the wound-healing of ulcer due to the reduction of acid out-put and only a transient decrease of PGE2, however, mucosal blood flow decreased after vagotomy.