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07:57
Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
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The anterior gradient-2 interactome.
Frederic Delom1,2,3, M Aiman Mohtar4, Ted Hupp5,6
1University of Bordeaux, ACTION, Bordeaux, France.
American Journal of Physiology. Cell Physiology
|October 24, 2019
Summary
Anterior gradient-2 (AGR2), an ER protein, impacts cancer progression. This review details AGR2
Area of Science:
- Molecular Biology
- Cancer Research
- Cell Biology
Background:
- Anterior gradient-2 (AGR2) is an endoplasmic reticulum (ER)-resident protein within the protein disulfide isomerase family.
- AGR2 plays a crucial role in ER protein quality control and disulfide bond formation.
- Extracellular AGR2 influences cancer cell proliferation, survival, and metastasis.
Purpose of the Study:
- To summarize the AGR2 interactome, identifying its binding partners.
- To discuss the physiological and pathological roles of AGR2 interactions.
- To explore the functional significance of AGR2's monomeric and homodimeric forms.
Main Methods:
- Utilized various OMICs approaches to identify AGR2 binding partners.
- Reviewed existing literature on AGR2 functions and interactions.
- Analyzed data concerning AGR2's monomeric and homodimeric structures.
Main Results:
- Identified a range of AGR2 binding partners through OMICs studies.
- Confirmed that AGR2 exists in both monomeric and homodimeric forms.
- Demonstrated that different AGR2 forms interact with distinct partners, leading to varied biological outcomes.
Conclusions:
- The AGR2 interactome is complex, involving diverse partners and functions.
- AGR2's structural forms (monomer and dimer) dictate its biological activities.
- Understanding AGR2 interactions is vital for elucidating its role in cancer and other diseases.
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