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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

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Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation

Julia M Laufer1, Mark A Hauser2, Ilona Kindinger2

  • 1Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Unterseestrasse 47, 8280 Kreuzlingen, Switzerland; Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstrasse 10, 78464 Konstanz, Germany.

Cell Reports
|October 24, 2019
PubMed

Keywords:
CCR7Rac1SrcVav1cell migrationchemokineendomembrane signalingβ-arrestin

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