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Updated: Jan 5, 2026
Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
Polymeric microneedles for controlled transdermal drug delivery
Parbeen Singh1, Andrew Carrier2, Yongli Chen1
1Postdoctoral Innovation Practice Base, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen, 518055, China; Department of Biological Applied Engineering, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen, 518055, China.
Polymeric microneedle (MN) systems offer controlled transdermal drug delivery. These biocompatible systems enable painless skin penetration for effective systemic drug absorption and tailored therapeutic dosing.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Polymeric microneedle (MN) systems are advanced transdermal drug delivery platforms.
- They offer tunable properties and ease of patient self-administration.
- Their biocompatibility allows for painless penetration of the stratum corneum.
Purpose of the Study:
- To review mechanisms of controlled drug delivery using polymeric MNs.
- To evaluate new strategies and applications in this field.
- To discuss the future outlook of polymeric MN technology.
Main Methods:
- Literature review of polymeric microneedle systems.
- Analysis of drug release kinetics and control mechanisms.
- Evaluation of polymer degradation and drug diffusion profiles.
Main Results:
- Polymeric MNs facilitate controlled drug release through polymer modification.
- They enable targeted delivery and response to physiological conditions.
- Successful adsorption into systemic circulation via dermal delivery.
Conclusions:
- Polymeric MNs represent a promising approach for controlled transdermal drug delivery.
- Modifying polymer and drug diffusion profiles is key to therapeutic dosing.
- Further research into new strategies and applications is warranted.
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