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Association of ABO blood groups with the severity of coronary artery disease: a cross-sectional study

Xu-Lin Hong1, Ya Li1, Guo-Sheng Fu1

  • 1Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Journal of Geriatric Cardiology : JGC
|October 25, 2019
PubMed

Insights

Blood group A is linked to more severe coronary artery disease (CAD). This finding was observed in Chinese individuals, including those with type 2 diabetes, suggesting blood type A as a risk factor for CAD severity.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Epidemiology

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • The role of genetic factors, such as ABO blood groups, in CAD severity is an area of ongoing research.
  • Understanding these associations can inform risk stratification and prevention strategies.

Purpose of the Study:

  • To determine if ABO blood groups are associated with the severity of coronary artery disease (CAD).
  • To investigate the independent risk factor potential of blood group A for CAD severity.

Main Methods:

  • A cross-sectional study involving 1425 newly diagnosed CAD patients.
  • Data collection included baseline characteristics, ABO blood groups, and Gensini scores.
  • Multiple linear regression analysis was employed to assess the association between CAD severity and ABO blood groups.

Main Results:

  • Blood group A demonstrated a significantly higher Gensini score compared to non-A blood groups (41.2 ± 32 vs. 38 ± 27; P = 0.026).
  • Multivariate analysis confirmed that blood group A is independently associated with increased CAD severity (β = 3.298, P = 0.044).
  • In patients with diabetes, blood group A was also linked to a higher Gensini score (P = 0.02).

Conclusions:

  • Blood group A is an independent risk factor for the severity of coronary artery disease.
  • This association was observed in the Chinese population and specifically in Chinese patients with type 2 diabetes.
Abstract

Keywords:
ABO blood groupsCoronary artery diseaseCross-sectional study

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