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Allosteric pathway selection in templated assembly.

Martijn van Galen1, Ruben Higler1, Joris Sprakel1

  • 1Physical Chemistry and Soft Matter, Wageningen University and Research, Stippeneng 4, 6708 WE Wageningen, Netherlands.

Science Advances
|October 25, 2019
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Summary
This summary is machine-generated.

This study introduces a minimal model for template-guided molecular self-assembly. It demonstrates how allosteric activation can steer assembly onto the desired pathway, avoiding unwanted aggregation.

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Area of Science:

  • Supramolecular chemistry
  • Nanomaterials science
  • Chemical kinetics

Background:

  • Self-assembly of molecular building blocks into functional nanostructures is complex.
  • Nature utilizes molecular templates for high-fidelity assembly.
  • Man-made nanomaterials lag in exploiting templating strategies.

Purpose of the Study:

  • To develop a minimal model for understanding templated molecular self-assembly kinetics.
  • To investigate pathway selection and suppression of trapped states in templated assembly.
  • To elucidate how building block design influences assembly pathways.

Main Methods:

  • Development of a minimal theoretical model.
  • Analysis of kinetic pathways and pathway selection.
  • Simulation of molecular building block assembly on a template.

Main Results:

  • Identified key factors governing pathway selection in templated assembly.
  • Demonstrated that allosteric activation of associative interactions suppresses solution-aggregation.
  • Showcased a pathway leading to true template-assembly.

Conclusions:

  • Precise control over self-assembly requires understanding building block interactions and energy landscapes.
  • Allosteric activation is a viable strategy to direct molecular assembly towards desired nanostructures.
  • This work provides a foundation for designing advanced man-made templated self-assembling systems.