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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Glycemic variability is associated with myocardial damage in nondiabetic patients with ST-elevation myocardial

Satoshi Oka1, Juntaro Deyama1, Ken Umetani1

  • 1Department of Cardiology, Yamanashi Prefectural Central Hospital, Kofu, Yamanashi Prefecture, Japan.

Cardiovascular Endocrinology & Metabolism
|October 25, 2019
PubMed

Insights

Glycemic variability (GV) is linked to myocardial damage in non-diabetic patients post-percutaneous coronary intervention for myocardial infarction. Higher GV correlated with worse outcomes, suggesting GV is a significant factor in this patient group.

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Research

Background:

  • Glycemic variability (GV) is known to cause coronary microcirculatory disturbance and myocardial damage in diabetic patients with acute myocardial infarction.
  • The association between GV and myocardial damage in non-diabetic patients with acute myocardial infarction is not well understood.

Purpose of the Study:

  • To investigate the relationship between glycemic variability and myocardial damage in non-diabetic patients with ST-segment elevation myocardial infarction (STEMI).

Main Methods:

  • A continuous glucose monitoring system was used to assess GV in non-diabetic STEMI patients undergoing emergent percutaneous coronary intervention.
  • GV was quantified using the mean amplitude of glycemic excursions (MAGE).
  • Myocardial damage was evaluated by myocardial blush grade and ST-segment resolution (STRes).

Main Results:

  • The higher MAGE group exhibited significantly lower myocardial blush grade (p=0.001) and poorer ST-segment resolution (p=0.044) compared to the lower MAGE group.
  • Specifically, complete STRes was less frequent in the higher MAGE group (33.3% vs. 56.8%).
  • The higher MAGE group also showed a trend towards more instances of no STRes (30.6% vs. 10.8%).

Conclusions:

  • Glycemic variability is associated with myocardial damage in non-diabetic patients following percutaneous coronary intervention for ST-segment elevation myocardial infarction.
  • These findings highlight the importance of managing GV in this patient population to potentially improve cardiac outcomes.
Abstract

Keywords:
acute myocardial infarctionglycemic variabilitymyocardial damage

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