[Research advances in relationship between biological clock and cardiovascular diseases]

Area of Science:

• Chronobiology
• Cardiovascular Physiology
• Molecular Medicine

Background:

• Circadian rhythms are endogenous biological processes present in most living organisms.
• These rhythms are controlled by the molecular biological clock.
• The cardiovascular system exhibits significant circadian variation in function.

Purpose of the Study:

• To review recent research on the relationship between the circadian clock and cardiovascular diseases.
• To highlight the role of circadian rhythm disruption as a risk factor for cardiovascular conditions.
• To explore potential therapeutic strategies based on biological clock theory for cardiovascular disease management.

Main Methods:

• Literature review of recent scientific publications.
• Synthesis of research findings on circadian clock mechanisms and cardiovascular physiology.
• Analysis of studies linking circadian disruption to cardiovascular disease pathogenesis.

Main Results:

• Circadian rhythms influence key cardiovascular functions: blood pressure, heart rate, cardiomyocyte metabolism, endothelial cell function, and vascular tone.
• Disruption of circadian rhythms is increasingly recognized as a significant risk factor for cardiovascular diseases, including myocardial infarction.
• The biological clock plays a critical role in maintaining cardiovascular homeostasis.

Conclusions:

• Understanding the interplay between the circadian clock and the cardiovascular system is crucial.
• Circadian rhythm disruption is a modifiable risk factor for cardiovascular diseases.
• Leveraging biological clock theory may offer novel therapeutic avenues for cardiovascular disease treatment.