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Progress in regulatory peptide research.

Limei Zhang1, Lee E Eiden2

  • 1Departmento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.

Annals of the New York Academy of Sciences
|October 25, 2019
PubMed
Summary
This summary is machine-generated.

Regulatory peptide research is advancing rapidly, with new peptide drugs approved for metabolic disorders and improved delivery methods. Advances in drug discovery and understanding receptor interactions are driving innovation in therapeutic peptide development.

Keywords:
GPCRhormoneneurotransmitterregulatory peptidetherapeutic

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Area of Science:

  • Pharmacology and Therapeutics
  • Biochemistry
  • Drug Discovery

Background:

  • The field of regulatory peptide research has gained significant momentum.
  • Numerous peptide-based drugs have been approved, primarily for metabolic disorders like diabetes.
  • Challenges in peptide drug delivery, stability, and bioavailability are being overcome.

Purpose of the Study:

  • To provide a snapshot of the current frontiers in regulatory peptide research.
  • To highlight advancements in physiological, pharmacological, and therapeutic applications.
  • To explore the impact of recent trends on drug design and discovery.

Main Methods:

  • Leveraging cell-based high-throughput drug discovery.
  • Utilizing X-ray crystallography for G protein-coupled receptor structural definition.
  • Employing receptor deorphanization techniques.

Main Results:

  • Overcoming traditional impediments in peptide drug delivery, stability, and bioavailability.
  • Progress in pharmaceutical delivery of peptides to the central nervous system via nasal routes.
  • Identification of new targets and accelerated development of peptide and non-peptide drugs.

Conclusions:

  • Regulatory peptide research is expanding, driven by technological and conceptual advances.
  • The combinatorial actions of peptides in cellular contexts are increasingly recognized.
  • These developments are significantly impacting drug design and discovery efforts.