Insulin resistance: Relationship between indices during late gestation in dairy cows and effects on newborn...

To investigate the relationship between insulin resistance indices ["Revised quantitative insulin sensitivity check index" (RQUICKI; RQ), "Revised quantitative insulin sensitivity check index - β-hydroxybutyrate" (RQUICKI_BHB ; RQ_BHB ), and "Homeostasis model assessment-insulin resistance" (HOMA-IR; HR)], and metabolic parameters in dams during late gestation, and their newborn calves. Blood was sampled twice weekly during the experimental period in 30 dry Holstein cows. In calves, blood sampling and body weight measurements were performed immediately after birth, and in 1-week-old male calves, liver and muscle biopsy samples were obtained for determining metabolic factor mRNA levels. RQ and RQ_BHB were negatively correlated with insulin, nonesterified fatty acid, BHB, and albumin and were positively correlated with leptin levels in blood during late gestation (p < .05). RQ, rather than RQ_BHB , reflected metabolism of dams, while stronger positive correlations were present between HR and blood insulin concentrations than other parameters, and calves of dams with high HR had low body weight, and high liver and muscle expression of growth hormone and insulin receptor mRNA (p < .05). RQ and HR of dams during late gestation could serve as indicators of dam metabolism and predictors of metabolism in newborn calves respectively.