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Updated: Jan 5, 2026
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
miR-146a and miR-152 in prostate cancer and clinicopathological parameters
Ye Liu1, Saiyue Gao, Qingyan Du
1Clinical Laboratory, Jining No.1 People's Hospital, Jining 272000, P.R. China.
Purpose:
To investigate the expression of miR-146a and miR-152 in the serum of patients with prostate cancer and the relationship between their expression and clinicopathologic parameters.
Methods:
56 patients with prostate cancer and 56 healthy volunteers were included in this study and the relationship between the expression levels of miR-146a and miR-152 and the clinicopathological parameters of the patients with prostate cancer were analyzed. ROC curve was used to search the diagnostic value of each indicator.
Results:
The expression of miR-146a in patients in the cancer group was significantly higher than that in the normal group (p<0.05). The expression of miR-152 in the cancer group was significantly lower than that in the normal group (p<0.05). The expression level of miR-146a in the patients with prostate cancer was closely related to clinical staging, the presence or absence of bone metastasis, tPSA and pathological staging (p<0.001) and the expression level of miR-152 in the patients with prostate cancer was closely related to clinical staging, the presence or absence of bone metastasis and pathological staging (p<0.001).
Conclusion:
The expression level of miR-146a showed a trend of up-regulation in prostate cancer, and the expression level of miR-152 had a trend of down-regulation in prostate cancer, and the results of partial correlation analysis showed that the expression level of miR-146a and miR-152 was negatively correlated with each other in the serum of the patients with prostate cancer.
