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Cyclobutastellettolides A and B, C19 Norterpenoids from a Stelletta sp. Marine Sponge
Sophia A Kolesnikova1, Ekaterina G Lyakhova1, Anatoly I Kalinovsky1
1G.B. Elyakov Pacific Institute of Bioorganic Chemistry, the Far Eastern Branch of the Russian Academy of Sciences , Vladivostok-22, Prospect 100-let , Vladivostoku 159 , Russia.
Abstract:
Two novel C19 terpenoids (1, 2) with an unprecedented carbon skeleton (A) were isolated from a Stelletta sp. sponge collected from Vietnamese waters. Their structures and absolute configurations were established by extensive NMR, MS, and ECD analyses together with quantum chemical modeling and biogenetic considerations. The probable pathways of biogenesis of 1 and 2 from isomalabaricane triterpenoids are discussed. Compounds 1 and 2 significantly increase the production of reactive oxygen species in murine peritoneal macrophages.
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