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Updated: Jan 5, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Photo-controlled chirality transfer and FRET effects based on pseudo[3]rotaxane
Hong-Guang Fu1, Heng-Yi Zhang1, Hao-Yang Zhang1
1Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. yuliu@nankai.edu.cn.
Abstract:
The use of light to regulate the chirality of supramolecular assemblies in a non-invasive manner remains a challenge. Herein, we report a novel photochromic pseudo[3]rotaxane based on a (R/S)-2,2'-binaphthyl secondary ammonium salt guest (2) and anthracene-bridged bis(dibenzo-24-crown-8) (1), which features a chirality transfer and fluorescence resonance energy transfer (FRET) from 2 to 1. Benefiting from the photo-oxidation of anthracene, the induced circular dichroism (ICD) signals of (R/S)-2@1 can be switched off/on by irradiation with 365 nm UV light and heating. This noncovalent supramolecular assembly strategy provides us with unique opportunities to design and construct further smart photo-responsive chiral molecular switches.
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