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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

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Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
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Does Physician Retirement Affect Patients? A Systematic Review.

Kenneth Lam1,2, Cameron G Arnold3, Rachel D Savage1

  • 1Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.

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|October 25, 2019
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Physician retirement can negatively impact patients, leading to adverse events and care difficulties. More research is needed to understand the full effects on patient outcomes and the healthcare system.

Keywords:
continuity of patient carehealth workforcephysiciansretirementtransitions of care

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Area of Science:

  • Geriatrics
  • Health Services Research
  • Patient Care

Background:

  • Long-term patient-physician relationships are common, particularly for older adults.
  • Physician retirement represents a significant disruption to continuity of care.
  • The impact of physician retirement on patient outcomes remains unclear.

Purpose of the Study:

  • To systematically review and synthesize existing literature on the association between physician retirement and patient outcomes.
  • To identify potential risks and benefits associated with the transition of care following physician retirement.

Main Methods:

  • A systematic review of English-language articles from Medline, Embase, Cochrane, and PsycINFO databases was conducted.
  • Studies were included if they examined patients whose generalist or specialist physician retired.
  • Patient outcomes were categorized, and study quality was assessed by two independent reviewers.

Main Results:

  • Seventeen articles met inclusion criteria, predominantly qualitative studies and anecdotes.
  • Most reported patient outcomes were unfavorable, including emotional distress, care transition difficulties, adverse clinical events, and increased healthcare costs.
  • Qualitative studies indicated patient vulnerability during physician transitions, while quantitative study quality was generally poor.

Conclusions:

  • Existing qualitative evidence suggests physician retirement negatively affects patients, highlighting their vulnerability during care transitions.
  • There is a significant lack of high-quality quantitative research to confirm these findings and assess impacts on older adults and the healthcare system.