Related Experiment Video
Updated: Jan 5, 2026
08:59
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
11.2K
Nervous system and gastric cancer
Ke Wang1, Xin-Hui Zhao1, Jun Liu2
1State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an, China; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.
Biochimica Et Biophysica Acta. Reviews on Cancer
|October 25, 2019
Summary
The nervous system directly and indirectly impacts gastric cancer by interacting with cancer cells and the tumor microenvironment. Understanding these neuro-gastric interactions offers new diagnostic and prognostic biomarkers for gastric cancer.
Area of Science:
- Oncology
- Neuroscience
- Gastroenterology
Background:
- The nervous system's role in gastric cancer is increasingly recognized, involving direct and indirect mechanisms.
- Gastric cancer cells interact with nerve fibers, promoting neural outgrowth, while nerves infiltrate tumors, fostering cancer progression.
- Neuro-immune interactions are crucial in gastric cancer development.
Purpose of the Study:
- To review recent advancements in understanding the nervous system's influence on gastric cancer.
- To explore the mechanisms mediating the interplay between nerves and gastric cancer.
- To discuss the diagnostic and prognostic potential of nervous system-associated factors in gastric cancer.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of studies on neuro-gastric interactions in cancer.
- Examination of clinical research on biomarkers.
Main Results:
- Nervous system-gastric cancer crosstalk occurs through direct cell-cell contact and indirect signaling.
- Nervous system-associated factors, produced by cancer cells and nerve terminals, regulate proliferation, angiogenesis, metastasis, and recurrence.
- Several of these factors show promise as diagnostic and prognostic biomarkers for gastric cancer.
Conclusions:
- The bidirectional communication between the nervous system and gastric cancer is a critical factor in tumor progression.
- Targeting neuro-gastric interactions and utilizing associated biomarkers may offer novel therapeutic and diagnostic strategies for gastric cancer.
- Further research into these interactions is essential for advancing gastric cancer management.
Related Concept Videos
01:37Neural Regulation
43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K
01:27Nerve Supply of the GI Tract
3.2K
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...
3.2K
01:21Nervous System
3.2K
The nervous system coordinates body functions through its complex network of nerve cells, enabling sensation and movement. It is divided into two primary parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord. The brain acts as the body's control center, processing sensory information and coordinating responses. The spinal cord functions as a major signaling pathway for the brain and the rest of the body.
3.2K
01:16Gastric Motility
2.7K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
2.7K
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
502
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
502
01:19Psychoneuroimmunology: Diabetes and Cancer
385
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
385