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Techniques to Induce and Quantify Cellular Senescence
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The development of cell senescence.

Sabela Da Silva-Álvarez1, Pilar Picallos-Rabina1, Lucía Antelo-Iglesias1

  • 1Laboratorio de Células Madre en Cáncer y Envejecimiento, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.

Experimental Gerontology
|October 25, 2019
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Summary

Cellular senescence, once viewed as a stress response, is now recognized in embryonic development across diverse species. This developmental role offers new insights into its functions and potential links to human developmental disorders.

Keywords:
DevelopmentEmbryogenesisSenescence

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Area of Science:

  • Cellular Biology
  • Developmental Biology
  • Evolutionary Biology

Background:

  • Cellular senescence was traditionally understood as a protective stress response limiting damaged cell proliferation.
  • Recent discoveries reveal programmed cellular senescence occurring during embryonic development.

Purpose of the Study:

  • To explore the role and characteristics of developmental senescence.
  • To understand the diverse functions of senescence beyond stress response.
  • To investigate the potential link between developmental senescence and human pathologies.

Main Methods:

  • Comparative analysis of senescence across different species (mammals, fish).
  • Identification of senescence occurring at specific developmental stages and sites.
  • Characterization of shared and unique features of developmental vs. stress-induced senescence.

Main Results:

  • Developmental senescence is observed in evolutionarily distant organisms.
  • This process shares traits with stress-induced senescence but has distinct characteristics.
  • Examples of developmental senescence highlight diverse biological functions.

Conclusions:

  • Cellular senescence plays a crucial role in embryonic development, not just stress response.
  • Understanding developmental senescence can illuminate its broader functions.
  • Alterations in developmental senescence may contribute to human developmental syndromes.